Case-control studies with affected sibships
نویسندگان
چکیده
منابع مشابه
Case-control studies with affected sibships
Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a framework to test for association in a case-control design including affected sibships and unrelated controls. First, a corrected variance for the allele frequency difference between cases and controls was dir...
متن کاملSexes of affected cases in sibships containing two or more members with anencephaly or spina bifida.
A study has been made of the sexes of the affected within sibships containing two or more members with anencephaly or spina bifida (ASB). There is no clear evidence for variation between ASB-prone women in their propensity to bear affected cases of one sex rather than the other. It is suggested that the point should be regarded as open until further data have settled the issue.
متن کاملDesigning case-control studies.
Identification of confounding factors, evaluation of their influence on cause-effect associations, and the introduction of appropriate ways to account for these factors are important considerations in designing case-control studies. This paper presents designs useful for these purposes, after first providing a statistical definition of a confounding factor. Differences in the ability to identif...
متن کاملMatched Case-Control Studies
'National Cancer Institute, Biometric Research Branch, DCTD, Executive Plaza North, Room 739, 6130 Executive Boulevard, MSC 7434, Bethesda, Maryland 20892-7434, U.S.A. 2National Cancer Institute, Biometry Research Group, DCP, Executive Plaza North, Room 344, 6130 Executive Boulevard, Bethesda, Maryland 20892, U.S.A. 3F0x Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 1911...
متن کاملCase-control studies.
Case-control studies investigate associations between exposures to risk factors and a condition of interest. Subjects with the condition (cases) are compared to subjects known not to have the condition (controls) with respect to the presence of risk factors in the past. This design is particularly useful when the condition of interest is relatively uncommon. Case-control studies are useful for ...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2007
ISSN: 1753-6561
DOI: 10.1186/1753-6561-1-s1-s29